Alendronic acid
Postmenopausal Osteoporosis, Extramammary Paget Disease
DRUG STATUS
Approvals
US(FDA), UK(BNF)
Essential Medicine
NO
Teratogenicity
Unlisted
Pharmaceutical Class
Bisphosphonate

Alendronic acid
Know More About This Medicine -
Click HereSummary
Alendronic Acid is used to prevent and treat weak bones (osteoporosis) in postmenopausal women and men. It is also beneficial for people whose bones have weakened due to steroid medications, and those with a bone disease called Paget's disease.
Alendronic Acid works by inhibiting bone resorption. It sticks to the bone and stops the cells that break down bone from working, which slows down bone loss and indirectly helps bone building.
For osteoporosis treatment, the dosage is 10 mg daily or 70 mg weekly. For prevention, it's 5 mg daily or 35 mg weekly. For Paget's disease, it's 40 mg daily for 6 months. Always follow your doctor's prescription.
Common problems include stomach upset, pain, heartburn, constipation, diarrhea, nausea, and aches in bones, joints, or muscles. Rarely, more serious problems like esophagus problems, low calcium, severe bone pain, jaw problems, or unusual thigh bone fractures can happen.
Alendronic Acid can cause serious problems like trouble swallowing, low calcium, bone pain, jaw problems, and broken bones. Take it exactly as directed, drink a full glass of water with it, stay upright for at least 30 minutes afterward, and tell your doctor right away if you have chest pain, heartburn, or trouble swallowing. Ensure your calcium levels are okay before you start taking this medicine.
Indications and Purpose
What is Alendronic acid used for?
Alendronate sodium tablets help strengthen bones. They're used for women after menopause to prevent and treat weak bones (osteoporosis). Men with weak bones can also use them to build stronger bones. The tablets also help people whose bones have weakened due to steroid medications, and those with a bone disease called Paget's disease.
How does Alendronic acid work?
Alendronate is a medicine that slows down bone loss. It works by stopping the cells that break down bone from working as much. This helps strengthen bones, but it doesn't directly build new bone. Taking it for a while (up to five years) can significantly reduce bone loss. It comes in different pill sizes and a liquid form.
Is Alendronic acid effective?
Alendronate is a medicine that helps make bones stronger. Studies show it's very effective for women who have osteoporosis after menopause. It significantly reduces the chances of breaking a bone in their spine and helps prevent them from getting shorter. It also works well for people who develop osteoporosis from taking certain medications (like glucocorticoids), increasing bone density in the spine and hip. The positive effects continue even after two years of treatment.
How does one know if Alendronic acid is working?
Four big studies showed that alendronate helps women after menopause who have weak bones. These studies looked at over 7000 women and found that their bones got stronger in different places (spine, hip, and overall) within just three months, and this improvement continued for three years. It also greatly reduced the chance of spine fractures. The drug worked well for women of all ages, races, and bone health levels.
Directions for Use
What is the usual dose of Alendronic acid?
- Osteoporosis treatment: 10 mg once daily or 70 mg once weekly.
- Osteoporosis prevention: 5 mg daily or 35 mg weekly.
- Paget's disease: 40 mg daily for 6 months.Always follow your doctor’s prescription.
How do I take Alendronic acid?
Take your medicine once a week, on the same day, right after you wake up. Drink only water with it. Wait at least half an hour before eating or lying down. If you forget, take it the next morning. Never take two doses at once.
For how long do I take Alendronic acid?
Doctors decide how long someone should take alendronate. There's no set time for everyone. It depends on the person's individual needs and how their body responds to the medicine.
How long does it take for Alendronic acid to start working?
Alendronate helps slow bone loss quickly, showing improvement within a month and reaching its peak effect after three to six months. However, we don't know exactly how long it continues to work effectively to prevent or treat osteoporosis, so regular checkups with your doctor are very important.
How should I store Alendronic acid?
Keep the container in a cool, dry place, between 68 and 77 degrees Fahrenheit. The container should be tightly closed and protected from light, and it should have a childproof cap.
Warnings and Precautions
Who should avoid taking Alendronic acid?
Alendronate sodium is a strong medicine that can cause serious problems like trouble swallowing, low calcium, bone pain, jaw problems, and broken bones. To stay safe, take it exactly as directed: drink a full glass of water with it, stay standing or sitting upright for at least 30 minutes afterward before eating anything, and tell your doctor right away if you have chest pain, heartburn, or trouble swallowing. Make sure your calcium levels are okay before you start taking this medicine.
Can I take Alendronic acid with other prescription drugs?
Alendronate is a medication that's best taken on an empty stomach, at least 30 minutes before eating or drinking anything other than plain water. Taking it with calcium, antacids, or certain other medicines can stop it from working properly. Taking more than 10mg a day or taking it with aspirin can cause more stomach upset. While it's okay to take it with other pain relievers like ibuprofen (NSAIDs), be careful as it might still bother your stomach.
Can I take Alendronic acid with vitamins or supplements?
Alendronate is a medicine that needs a special environment in your stomach to work properly. Taking it with calcium, antacids (for heartburn), or certain other medicines can stop it from being absorbed correctly. So, wait at least half an hour after taking alendronate before taking anything else by mouth. Older adults, people who are sick a lot, or those with problems absorbing nutrients might also need extra vitamin D to help the alendronate work better. Getting enough calcium and vitamin D is especially important if you're taking medicine like glucocorticoids.
Can Alendronic acid be taken safely while pregnant?
Alendronate is a medicine that shouldn't be taken during pregnancy. We don't know for sure how it might affect a mother or her baby, but animal studies show it could harm the baby's bones. Since there's a chance of problems, and we don't have enough information about its safety, it's best to stop taking it if you become pregnant. Keep in mind that there's a small chance of birth defects or miscarriage even without taking this medicine.
Can Alendronic acid be taken safely while breastfeeding?
We don't know if the medicine alendronate passes into breast milk, affects milk supply, or hurts babies who are breastfed. Doctors need to weigh the benefits of breastfeeding against the mom's need for the medicine and any possible risks to the baby.
Is Alendronic acid safe for the elderly?
Older adults need enough calcium and vitamin D. If they don't get enough from food, they might need extra vitamin D, especially if they're over 70, can't leave home easily, or are often sick. Some people need even more vitamin D, especially if they have stomach problems. Take your alendronate pill first thing in the morning with plain water, at least 30 minutes before eating or drinking anything else. Stay sitting or standing for at least 30 minutes after taking it and after your first meal. If you miss a dose, take it the next morning; don't take two pills at once. Tell your doctor right away if you have trouble swallowing, chest pain, or heartburn.
Is it safe to exercise while taking Alendronic acid?
Yes, exercise is encouraged, especially weight-bearing exercises, to support bone health. Avoid high-impact activities if you have a high risk of fractures.
Is it safe to drink alcohol while taking Alendronic acid?
The statement means that while moderate drinking might not directly affect how well your osteoporosis medicine (alendronate) works, heavy drinking could. If you drink a lot, it's best to cut back because it could interfere with your treatment.